2,3-Dihalofenolessustratos de partida versátiles para la síntesis de heterociclos funcionalizados regioselectivamente
- Guilarte Moreno, Verónica
- Roberto Sanz Díez Director
Defence university: Universidad de Burgos
Fecha de defensa: 18 May 2012
- José María Quintela López Chair
- Manuel Ángel Fernández Rodríguez Secretary
- Juan Manuel Cuerva Carvajal Committee member
- Yolanda Fernández Sainz Committee member
- Rosana Álvarez Rodríguez Committee member
Type: Thesis
Abstract
This Thesis has been focused on the preparation of different functionalized heterocycles that show considerable importance in Organic Chemistry because they constitute the core of a wide variety of compounds with biological or pharmacological properties. In this field, we have developed efficient routes to the synthesis of regioselectively functionalized indoles, benzo[b]furans and benzo[b]thiophenes. The directed ortho-metalation strategy in conjunction with palladium-catalyzed cross-coupling reactions have been mainly used to achieve this goal. The potential of these synthetic routes is that they allow an easy access to a wide variety of interesting products in a regioselective way by employing commercially or easily available starting materials. In addition, these strategies generally involve an improvement in relation to existing methodologies due to their selectivity and simplicity.