Poly(phenylacetylene)s with peptide substituentsstructure and applications
- Suárez Picado, Esteban
- Emilio Quiñoá Cabana Zuzendaria
- Félix Manuel Freire Iribarne Zuzendarikidea
Defentsa unibertsitatea: Universidade de Santiago de Compostela
Fecha de defensa: 2019(e)ko abendua-(a)k 19
- Jaime Rodríguez Presidentea
- María Magdalena Cid Fernández Idazkaria
- Jeanne Crassous Kidea
Mota: Tesia
Laburpena
This Doctoral Thesis is focused on the preparation of brand new peptide-based poly(phenylacetylene)s (PPAs) with targeted functions. Polymeric systems based on biomimetic structures allowed developing stimuli-responsive materials in both water and organic media with potential applications as sensors where controlled conformational changes at pendants lead a preferred helical sense in highly dynamic PPAs studied. Moreover, a novel macromolecular gear was designed, bearing a helical pendant moiety that is able to promote a specific helical sense and scaffold, depending on solvent changes. Finally, a new family of water-soluble helical polymers were generated to evaluate their sensorial abilities when facing different external stimuli such as metal ions, solvent, chiral or achiral molecules, or even pH.