Efecto de FZ sobre el control glucémico en ratas diabéticas

Abstract

INTRODUCTION. FZ captures glucose selectively, showing a similar effect like anti-hiperglucemiants, (Acarbosa, Fibraguar and the Miglitol). OBJECTIVE. To demonstrate the therapeutic potential of FZ on an experimental model of diabetes rats. MATERIAL AND METHOD. Forty Wistar rats of 60 days born were utilized. The diabetes was induced by Streptozotocin administration. The glycaemia levels were measured three days after the injection; the animals that proved to be hyperglycaemic were distributed in two homogeneous groups according to weight and glucose levels. A load of 1 and 5g of glucose for Kg were orally administrated, after glucose administration FZ treatment group dose of 0.1 mg for kg of weight of the rat was also administrated. We determined glucose levels in time after the treatment 15, 30, 45, 60, 90 and 120 minutes. RESULTS. The anti-hiperglucemiant effect was observed through the glucose blood levels and the calculated area under curve. Lower values and curved areas were observed in the FZ treatment than control group. Conclusions: The FZ treatment of rats with high glucose levels in blood reduces the areas under the curve of glucose absorption.