Detección y confirmación de la DTX-2, componente tóxico del grupo DSP, en mejillones gallegos
- Gago Martínez, Ana
- Rodriguez-Vazquez, J.A.
- Quilliam, M.A.
ISSN: 0212-7113
Year of publication: 1996
Volume: 13
Issue: 1
Pages: 32-36
Type: Article
More publications in: Revista de toxicología
Abstract
Diarrhetic shellfish poisoning (DSP) is a gastrointestinal illness caused by consumption of shellfish contaminated by certain toxic dinoflagellates. The main agents known to be responsible for the toxic effects are okadaic acid (OA) and the dinophysistoxins, DTX-1 and DTX-2. Until now the only DSP toxin found in Galician samples was okadaic acid. On some occasions, however, mussel samples that tested positive in the mouse bioassay showed only low levels of OA by liquid chromatography analysis. In these cases, an extra peak was sometimes observed in chromatograms close to that of OA. It was suspected that this might have been due to DTX-2. The presence of DTX-2 in 1990 and 1993 Galician mussels samples has now been confirmed by liquid chromatography-mass spectrometry.