Efectividad del ejercicio terapéutico en la “Unified Huntington´s Disease Rating Scale” en pacientes diagnosticados de Enfermedad de Huntington

  1. Irimia Mollinedo Cardalda 1
  2. Aurelia Vilas Pousada 1
  3. Pereira Pedro, Karina Pitombeira 1
  4. Oliveira, Iris Machado de 1
  1. 1 Universidade de Vigo
    info

    Universidade de Vigo

    Vigo, España

    ROR https://ror.org/05rdf8595

Journal:
Retos: nuevas tendencias en educación física, deporte y recreación

ISSN: 1579-1726,  1988-2041

Year of publication: 2024

Issue: 54

Pages: 807-816

Type: Article

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More publications in: Retos: nuevas tendencias en educación física, deporte y recreación

Abstract

Introduction: Huntington’s Disease is a neurodegenerative disorder of autosomal dominant inheritance which presents progressive motor, cognitive and psychiatric symptoms. There is no cure, only symptomatic treatment. This review is fulfilled with the aim of stablishing if exercise therapy is effective in the treatment of this pathology, according to the results obtained in the Unified Huntington Disease Rating Scale. Methods: A bibliographic search was performed in six databases (PubMed, Cinahl, Sportdiscus, Cochrane, PEDro, and Web of Science) in January 2022, following the Preferred Reported Items for Systematic Reviews and Meta-Analysis. Results: Eight randomized clinical trials were analyzed, among which six studies were found with significant results, with favorable impact on the motor dimension of the UHDRS, in addition to other variables such as heart rate, which are also favored during the intervention; and two studies without positive results for the variable. Conclusions: Exercise therapy seems to be a safe tool in treatment of Huntington’s Disease, as it has been proved that cardiovascular exercise, combined or not with strength training, seems to achieve improvements in the Unified Huntington’s Disease Rating Scale, therefore it has a positive impact on the physical and mental health of this type of patients, although intervention protocols need to be further unified, as well as keep on investigating.

Bibliographic References

  • Al-Wardat, M., Schirinzi, T., Hadoush, H., Kassab, M., Yabroudi, M. A., Opara, J., Nawrat-Szołtysik, A., Khalil, H., & Etoom, M. (2022). Home-Based Exercise to Improve Motor Functions, Cognitive Functions, and Quality of Life in People with Huntington’s Disease: A Systematic Review and Meta-Analysis. International Journal of Environ-mental Research and Public Health, 19(22), 14915. https://doi.org/10.3390/ijerph192214915
  • Bishnoi, A., Lee, R., Hu, Y., Mahoney, J. R., & Hernandez, M. E. (2022). Effect of Treadmill Training Interventions on Spatiotemporal Gait Parameters in Older Adults with Neurological Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Environmental Research and Public Health, 19(5), 2824. https://doi.org/10.3390/ijerph19052824
  • Blair, S. N., & Morris, J. N. (2009). Healthy Hearts—and the Universal Benefits of Being Physically Active: Physical Activity and Health. Annals of Epidemiology, 19(4), 253-256. https://doi.org/10.1016/j.annepidem.2009.01.019
  • Busse, M., Quinn, L., Debono, K., Jones, K., Collett, J., Playle, R., Kelly, M., Simpson, S., Backx, K., Wasley, D., Dawes, H., Rosser, A., & Members of the COMMET-HD Management Group. (2013). A randomized feasibility study of a 12-week community-based exercise program for people with Huntington’s disease. Journal of Neuro-logic Physical Therapy: JNPT, 37(4), 149-158. https://doi.org/10.1097/NPT.0000000000000016
  • Busse, M., Quinn, L., Drew, C., Kelson, M., Trubey, R., McEwan, K., Jones, C., Townson, J., Dawes, H., Tudor-Edwards, R., Rosser, A., & Hood, K. (2017). Physical Activity Self-Management and Coaching Compared to So-cial Interaction in Huntington Disease: Results From the ENGAGE-HD Randomized, Controlled Pilot Feasibility Trial. Physical Therapy, 97(6), 625-639. https://doi.org/10.1093/ptj/pzx031
  • Caron, N. S., Wright, G. E., & Hayden, M. R. (2020). Huntington Disease. En GeneReviews® [Internet]. University of Washington, Seattle. https://www.ncbi.nlm.nih.gov/books/NBK1305/
  • Cashin, A. G., & McAuley, J. H. (2020). Clinimetrics: Physiotherapy Evidence Database (PEDro) Scale. Journal of Physiotherapy, 66(1), 59. https://doi.org/10.1016/j.jphys.2019.08.005
  • Crowell, V., Houghton, R., Tomar, A., Fernandes, T., & Squitieri, F. (2021). Modeling Manifest Huntington’s Disease Prevalence Using Diagnosed Incidence and Survival Time. Neuroepidemiology, 55(5), 361-368. https://doi.org/10.1159/000516767
  • Dawes, H., Collett, J., Debono, K., Quinn, L., Jones, K., Kelson, M. J., Simpson, S. A., Playle, R., Backx, K., Was-ley, D., Nemeth, A. H., Rosser, A., Izardi, H., & Busse, M. (2015). Exercise testing and training in people with Huntington’s disease. Clinical Rehabilitation, 29(2), 196-206. https://doi.org/10.1177/0269215514540921
  • Fritz, N. E., Rao, A. K., Kegelmeyer, D., Kloos, A., Busse, M., Hartel, L., Carrier, J., & Quinn, L. (2017). Physical Therapy and Exercise Interventions in Huntington’s Disease: A Mixed Methods Systematic Review. Journal of Hun-tington’s Disease, 6(3), 217-235. https://doi.org/10.3233/JHD-170260
  • Ghosh, R., & Tabrizi, S. J. (2018). Clinical Features of Huntington’s Disease. En C. Nóbrega & L. Pereira de Almeida (Eds.), Polyglutamine Disorders (Vol. 1049, pp. 1-28). Springer International Publishing. https://doi.org/10.1007/978-3-319-71779-1_1
  • Jpt, H. (s. f.). Manual Cochrane de revisiones sistemáticas de intervenciones. 639.
  • Khalil, H., Quinn, L., van Deursen, R., Dawes, H., Playle, R., Rosser, A., & Busse, M. (2013). What effect does a structured home-based exercise programme have on people with Huntington’s disease? A randomized, controlled pilot study. Clinical Rehabilitation, 27(7), 646-658. https://doi.org/10.1177/0269215512473762
  • Kim, A., Lalonde, K., Truesdell, A., Gomes Welter, P., Brocardo, P. S., Rosenstock, T. R., & Gil-Mohapel, J. (2021). New Avenues for the Treatment of Huntington’s Disease. International Journal of Molecular Sciences, 22(16), 8363. https://doi.org/10.3390/ijms22168363
  • Luan, X., Tian, X., Zhang, H., Huang, R., Li, N., Chen, P., & Wang, R. (2019). Exercise as a prescription for patients with various diseases. Journal of Sport and Health Science, 8(5), 422-441. https://doi.org/10.1016/j.jshs.2019.04.002
  • McColgan, P., & Tabrizi, S. J. (2018). Huntington’s disease: A clinical review. European Journal of Neurology, 25(1), 24-34. https://doi.org/10.1111/ene.13413
  • McGuinness, L. A., & Higgins, J. P. T. (2021). Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Research Synthesis Methods, 12(1), 55-61. https://doi.org/10.1002/jrsm.1411
  • Memon, A. A., Coleman, J. J., & Amara, A. W. (2020). Effects of exercise on sleep in neurodegenerative disease. Neurobiology of Disease, 140, 104859. https://doi.org/10.1016/j.nbd.2020.104859
  • Mueller, S. M., Petersen, J. A., & Jung, H. H. (2019). Exercise in Huntington’s Disease: Current State and Clinical Significance. Tremor and Other Hyperkinetic Movements, 9(0), 601. https://doi.org/10.5334/tohm.515
  • PEDro_scale_spanish.pdf. (s. f.). Recuperado 2 de mayo de 2022, de https://pedro.org.au/wp-content/uploads/PEDro_scale_spanish.pdf
  • Quinn, L., Debono, K., Dawes, H., Rosser, A. E., Nemeth, A. H., Rickards, H., Tabrizi, S. J., Quarrell, O., Trender-Gerhard, I., Kelson, M. J., Townson, J., Busse, M., & members of the TRAIN-HD project group. (2014). Task-specific training in Huntington disease: A randomized controlled feasibility trial. Physical Therapy, 94(11), 1555-1568. https://doi.org/10.2522/ptj.20140123
  • Quinn, L., Hamana, K., Kelson, M., Dawes, H., Collett, J., Townson, J., Roos, R., van der Plas, A. A., Reilmann, R., Frich, J. C., Rickards, H., Rosser, A., & Busse, M. (2016). A randomized, controlled trial of a multi-modal exer-cise intervention in Huntington’s disease. Parkinsonism & Related Disorders, 31, 46-52. https://doi.org/10.1016/j.parkreldis.2016.06.023
  • Quinn, L., Kegelmeyer, D., Kloos, A., Rao, A. K., Busse, M., & Fritz, N. E. (2020). Clinical recommendations to guide physical therapy practice for Huntington disease. Neurology, 94(5), 217-228. https://doi.org/10.1212/WNL.0000000000008887
  • Roos, R. A. (2010). Huntington’s disease: A clinical review. Orphanet Journal of Rare Diseases, 5(1), 40. https://doi.org/10.1186/1750-1172-5-40
  • Salari, N., Hayati, A., Kazeminia, M., Rahmani, A., Mohammadi, M., Fatahian, R., & Shohaimi, S. (2022). The effect of exercise on balance in patients with stroke, Parkinson, and multiple sclerosis: A systematic review and meta-analysis of clinical trials. Neurological Sciences, 43(1), 167-185. https://doi.org/10.1007/s10072-021-05689-y
  • Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: Elaboration and explanation. BMJ, 349, g7647. https://doi.org/10.1136/bmj.g7647
  • Smith, M., Barker, R., Williams, G., Carr, J., & Gunnarsson, R. (2020). The effect of exercise on high-level mobility in individuals with neurodegenerative disease: A systematic literature review. Physiotherapy, 106, 174-193. https://doi.org/10.1016/j.physio.2019.04.003
  • Stout, J. C., Jones, R., Labuschagne, I., O’Regan, A. M., Say, M. J., Dumas, E. M., Queller, S., Justo, D., Santos, R. D., Coleman, A., Hart, E. P., Dürr, A., Leavitt, B. R., Roos, R. A., Langbehn, D. R., Tabrizi, S. J., & Frost, C. (2012). Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington’s dis-ease. Journal of Neurology, Neurosurgery, and Psychiatry, 83(7), 687-694. https://doi.org/10.1136/jnnp-2011-301940
  • Sujkowski, A., Hong, L., Wessells, R. J., & Todi, S. V. (2022). The protective role of exercise against age-related neu-rodegeneration. Ageing Research Reviews, 74, 101543. https://doi.org/10.1016/j.arr.2021.101543
  • The HD Measuring Stick: Assessment Standards for Huntington’s Disease. (2010, julio 7). HOPES Huntington’s Dis-ease Information. https://hopes.stanford.edu/assessment-standards-for-huntingtons-disease-severity/
  • Thompson, J. A., Cruickshank, T. M., Penailillo, L. E., Lee, J. W., Newton, R. U., Barker, R. A., & Ziman, M. R. (2013). The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington’s disease: A pilot study. European Journal of Neurology, 20(9), 1325-1329. https://doi.org/10.1111/ene.12053
  • Trembath, M. K., Horton, Z. A., Tippett, L., Hogg, V., Collins, V. R., Churchyard, A., Velakoulis, D., Roxburgh, R., & Delatycki, M. B. (2010). A retrospective study of the impact of lifestyle on age at onset of Huntington disease. Movement Disorders, 25(10), 1444-1450. https://doi.org/10.1002/mds.23108
  • Trinkler, I., Chéhère, P., Salgues, J., Monin, M.-L., Tezenas du Montcel, S., Khani, S., Gargiulo, M., & Durr, A. (2019). Contemporary Dance Practice Improves Motor Function and Body Representation in Huntington’s Dis-ease: A Pilot Study. Journal of Huntington’s Disease, 8(1), 97-110. https://doi.org/10.3233/JHD-180315
  • UHDRS®. (s. f.). Recuperado 16 de mayo de 2022, de https://huntingtonstudygroup.org/uhdrs/
  • Unified Huntington’s disease rating scale: Reliability and consistency. (1996). Movement Disorders, 11(2), 136-142. https://doi.org/10.1002/mds.870110204
  • Wyant, K. J., Ridder, A. J., & Dayalu, P. (2017). Huntington’s Disease—Update on Treatments. Current Neurology and Neuroscience Reports, 17(4), 33. https://doi.org/10.1007/s11910-017-0739-9
Data source: Dialnet