Periprandial changes in brain serotonergic system and food intake related neuropeptides

  1. Chivite Alcalde, Mauro 1
  2. Míguez, Jesús Manuel 1
  3. Ceinos, Rosa María 1
  4. Lopez-Patiño, Marcos Antonio 1
  5. Cerda-Reverter, Jose Miguel 2
  6. Soengas, Jose Luis 1
  7. Aldegunde, Manuel 3
  1. 1 Universidade de Vigo
    info

    Universidade de Vigo

    Vigo, España

    ROR https://ror.org/05rdf8595

  2. 2 Consejo Superior de Investigaciones Científicas
    info

    Consejo Superior de Investigaciones Científicas

    Madrid, España

    ROR https://ror.org/02gfc7t72

  3. 3 Universidade de Santiago de Compostela
    info

    Universidade de Santiago de Compostela

    Santiago de Compostela, España

    ROR https://ror.org/030eybx10

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Editor: Dryad

Any de publicació: 2023

Tipus: Dataset

CC0 1.0

DOI: 10.5061/DRYAD.S7H44J1CQ lock_openAccés obert editor

Resum

In this work, we assessed periprandial serotonin and 5-hydroxyindolacetic acid abundance in several brain areas of rainbow trout, in parallel with the evaluation of gene expression of tryptophan hydroxilase 1 and 2, neuropeptides involved in the central control of food intake, and the quantification of plasma glucose and cortisol. The results showed severe changes in serotonergic systems around mealtime, the most prominent being the increase in their activity just after food intake, suggesting that serotonin has a relevant role in relation to the daily timing of food intake, probably triggering satiety signals. In addition, a temporal adjustment of neuropeptide expression and plasma cortisol was found in relation to food intake, supporting its role in the regulation of feeding behaviour.