Development and evolution of the vertebrate hypothalamusevidences in chondrichthyans
- Santos Durán, Gabriel Nicolás
- Isabel Rodríguez-Moldes Zuzendarikidea
- Eva Candal Suárez Zuzendarikidea
Defentsa unibertsitatea: Universidade de Santiago de Compostela
Fecha de defensa: 2015(e)ko abendua-(a)k 18
- Ramon Anadon Vazquez Presidentea
- Manuel A. Pombal Diego Idazkaria
- Philippe Vernier Kidea
- Luis V. Puelles López Kidea
- Agustín González Gallegos Kidea
Mota: Tesia
Laburpena
The hypothalamus is a conserved integrative center with a complex organization result of a complex patterning processes. Here we make use of a evo-devo approach and the theoretical framework of the prosomeric model to understand the organization of the vertebrate hypothalamus. We studied the gene expression patterns of ScFoxg1a, ScDlx2/5, ScOtp, ScShh, ScNkx2.1, ScTbr1, ScNeurog2, ScLhx5, ScLhx9, ScDlx2/5, ScNkx2.8, ScEmx2, ScLmx1b, ScPitx2, ScPitx3a, ScNeurog2, ScFoxa1 and ScFoxa2 besides immunoreactivity to Pax6, PCNA and other immunomarkers in the embryonic hypothalamus and neighbour prosencephalic territories of a cartilaginous fish, the catshark, Scyliorhinus canicula. Our comparative analysis reveals the existence of conserved traits but also suggests an alternative organization to that proposed by the prosomeric model for the hypothalamus and even for the anterior prosencephalon of vertebrates.