Development and evolution of the vertebrate hypothalamusevidences in chondrichthyans

  1. Santos Durán, Gabriel Nicolás
Dirigée par:
  1. Isabel Rodríguez-Moldes Co-directeur/trice
  2. Eva Candal Suárez Co-directeur/trice

Université de défendre: Universidade de Santiago de Compostela

Fecha de defensa: 18 décembre 2015

Jury:
  1. Ramon Anadon Vazquez President
  2. Manuel A. Pombal Diego Secrétaire
  3. Philippe Vernier Rapporteur
  4. Luis V. Puelles López Rapporteur
  5. Agustín González Gallegos Rapporteur

Type: Thèses

Teseo: 400310 DIALNET lock_openMINERVA editor

Résumé

The hypothalamus is a conserved integrative center with a complex organization result of a complex patterning processes. Here we make use of a evo-devo approach and the theoretical framework of the prosomeric model to understand the organization of the vertebrate hypothalamus. We studied the gene expression patterns of ScFoxg1a, ScDlx2/5, ScOtp, ScShh, ScNkx2.1, ScTbr1, ScNeurog2, ScLhx5, ScLhx9, ScDlx2/5, ScNkx2.8, ScEmx2, ScLmx1b, ScPitx2, ScPitx3a, ScNeurog2, ScFoxa1 and ScFoxa2 besides immunoreactivity to Pax6, PCNA and other immunomarkers in the embryonic hypothalamus and neighbour prosencephalic territories of a cartilaginous fish, the catshark, Scyliorhinus canicula. Our comparative analysis reveals the existence of conserved traits but also suggests an alternative organization to that proposed by the prosomeric model for the hypothalamus and even for the anterior prosencephalon of vertebrates.