Preparation and characterization of antigen loaded chitosan nanoparticles for immunization

  1. Prasanna, Maruthi
Dirigida per:
  1. Noemi Stefania Csaba Director/a
  2. Cyrille Grandjean Director/a

Universitat de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 11 de de setembre de 2020

Tribunal:
  1. Antonio José Almeida President/a
  2. Maria Victoria Lozano Lopez Secretari/ària
  3. Bernard Offmann Vocal
  4. María José Alonso Fernández Vocal
  5. Rosana Simón Vázquez Vocal

Tipus: Tesi

Resum

The currently available pneumococcal vaccines are not effective in complete prevention of pneumococcal infections. To develop a better vaccine, firstly, we produced a glycoconjugate antigen based on common pneumococcal vaccine. Based on the positive immune responses generated by the glycoconjugate antigen in the mice, we further envisage that their combination with the nanotechnologies would generate a vaccine with enhanced potential. In this line, we utilized chitosan nanoparticles to encapsulate the glycoconjugate. Finally, the developed nanovaccines generated an enhanced immune response against both the protein and polysaccharide components when compared to the naked glycoconjugate.